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In vitro dosimetry modeling will be a critical step toward efficient assessment of engineered nanomaterials for environmental health and safety
Citation:
Boyes, W. In vitro dosimetry modeling will be a critical step toward efficient assessment of engineered nanomaterials for environmental health and safety. Society of Toxicology Annual Meeting, New Orleans, LA, March 13 - 17, 2016.
Impact/Purpose:
Will be presented at the Society of Toxicology Annual Meeting March 13-17, 2015, New Orleans, LA.
Description:
Presentation Description: The development and application of engineered nanomaterials (ENM) into commercial and consumer products is far outpacing the ability of traditional approaches to evaluate the potential implications for environmental health and safety. This problem recently prompted the National Nanotechnology Initiative (NNI) to issue a grand challenge to the research and development community to develop the ability to "determine the environmental, health, and safety characteristics of a nanomaterial in a month". This presentation will consider a general framework in which to consider potential for ENM release, environmental fate, transformations, exposures and effects. Within this framework ,the role of in vitro dosimetry modeling will be illustrated experimentally with examples comparing applied, measured and modeled tissue dose levels of silver and titanium dioxide ENM to cells in vitro. To meet the NNI grand challenge will be difficult, and likely require a combination of targeted rapid screening approaches and predictive modeling. A key step will be the ability to understand the dose of ENM delivered to cells in test systems, along with the use of other modeling approaches to rapidly estimate both levels of exposure and hazardwithin bounds of uncertainty acceptable for the applications being considered