Citation:

Nesnow, S. MULTI-FACTOR POTENCY SCHEME FOR COMPARING THE CARCINOGENIC ACTIVITY OF CHEMICALS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/185 (NTIS PB92188911), 1991.

Description:

A scheme for ranking the quantitative activity `of chemical carcinogens is described. his activity scheme uses as its base, dose potency measured as TD50, which after conversion into an inverse log scale, a decile scale, is adjusted by weighing factors that describe other parameters of carcinogenic activity. hese factors include positive or negative weighing for: he induction of tumors at tissues or organs associated with high historical control tumor incidences; the induction of tumors at multiple sites; the induction of tumors in both sexes of the species; and the induction of tumors in more than one species. hese factors were chosen as they represented qualitative descriptions of the general specificity or non-specificity of chemicals with regard to the activity in rodents and have some bearing on the potential activity of chemicals in humans. n order to construct a measure to express the inactivity of chemicals towards the induction of cancer, a measure analogous to the TD50 has been developed: the highest average daily dose [HADD] in mg chemical/kg body weight administered in a chronic cancer study and that did not induce a statistical increase in tumors. ADD values were similarly converted to log decile units and adjusted by weighing factors according to lack of activity in both sexes of a species, and the lack of activity in more than one species. hree activity ranking chemes were developed: he Carcinogen Activity-F344 Rat, an activity scheme based on cancer data obtained with the F344 rat; the Carcinogen Activity-B6C3F1 Mouse, an activity scheme based on cancer data obtained with the B6C3F1 mouse, and the Carcinogen Activity Combined an activity scheme based on selecting data from both the F344 rat and B6C3F1.

URLs/Downloads:

Record Details:

Document IDs: