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CARCINOGENIC POTENTIAL OF ROTENONE. PHASE I: DIETARY ADMINISTRATION TO HAMSTERS
Citation:
Leber, A. AND R. Persing. CARCINOGENIC POTENTIAL OF ROTENONE. PHASE I: DIETARY ADMINISTRATION TO HAMSTERS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-79/004A.
Description:
Studies were performed to evaluate the potential carcinogenicity rotenone in the Syrian Golden hamster. Several ancillary range-finding studies were carried out including 14-day feeding trials and a reproduction experiment. The latter experiment indicated that rotenone at a level of 500 ppm in the maternal diet was embryo-toxic (depressed birth weight and fetal deaths) and resulted in cannabalism of the young by the maternal animals. A level of 1000 ppm led to sterility in one or both sexes. The 18-month carcinogenesis study indicated that 1000 ppm rotenone in the diet was toxic to hamsters (depressed body weights compared to controls) but no gross or histopathological evidence was obtained which indicated that the test compound induced the formation of any tumors. Three adrenal cortical carcinomas in 65 hamsters observed in the 1000 ppm group could not be ascribed to rotenone treatment.