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EFFECTS OF DIPHENYLHYDATOIN AND CHLOROQUINE ON MONKEY LIVER MICROSOMAL MIXED-FUNCTION OXIDASES
Citation:
Davis, J., M. Cramer, AND A. Peoples. EFFECTS OF DIPHENYLHYDATOIN AND CHLOROQUINE ON MONKEY LIVER MICROSOMAL MIXED-FUNCTION OXIDASES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-77/093 (NTIS PB278598), 1977.
Description:
Sixteen adult male squirrel monkeys (Saimiri sciureus) were randomly divided into three treatment groups and one control group. Each treatment group received 10 mg/kg oral doses of diphenylhydantoin and/or chloroquine. Following sacrifice, in vitro assays for activity of liver microsomal mixed-function oxidases were run. The assays confirmed diphenylhydantoin as a potent inducer of mixed-function oxidases. Chloroquine administration had little affect on the enzymes assayed and did not inhibit the diphenylhydantoin induction. (Copyright (c) 1977 by Hemisphere Publishing Corporation.)