You are here:
COMPARABILITY OF IN VITRO AND IN VIVO METHODS FOR THE DETERMINATION OF ALTERATIONS IN DRUG METABOLISM
Citation:
Carlson, G. AND R. Chadwick. COMPARABILITY OF IN VITRO AND IN VIVO METHODS FOR THE DETERMINATION OF ALTERATIONS IN DRUG METABOLISM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/316 (NTIS PB88196332), 1987.
Description:
The article reviews the use of model substrates to assess the capacity of the liver to metabolize xenobiotics via the myriad of drug metabolizing pathways available to it. The applicability of model compounds to act as predictors of in vivo drug metabolism in man and animals was evaluated, and the advantages and limitations of these assays are indicated. (Copyright (c) 1987 Elsevier Science Publishers B.V. (Biomedical Division.)
URLs/Downloads:
COMPARABILITY OF IN VITRO AND IN VIVO METHODS FOR THE DETERMINATION OF ALTERATIONS IN DRUG METABOLISMRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:12/31/1987
Record Last Revised:12/22/2005
Record ID:
32918