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DESIGN AND CHARACTERIZATION OF A SMALL CHAMBER FOR CHEMICAL AND BIOLOGICAL EVALUATION OF SOURCES OF INDOOR AIR CONTAMINATION
Citation:
Mason, M., N. Roache, AND D. Costa. DESIGN AND CHARACTERIZATION OF A SMALL CHAMBER FOR CHEMICAL AND BIOLOGICAL EVALUATION OF SOURCES OF INDOOR AIR CONTAMINATION. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-95/092 (NTIS PB95232831), 1994.
Description:
The paper discusses exposure generation considerations prior to implementation of sensory irritation bioassays for product emissions. mall chambers are used to generate source emissions from products for chemical and biological evaluation. esign of the source emissions chamber and test protocols affect results of the chemical and biological characterization. f the goal of biological testing is to predict human response from an animal system, it is necessary to obtain concentration dependent (or dose-response) data in the region of response of the test animal and extrapolate to human expose conditions. f the test system is less sensitive than humans, source emissions must be increased to obtain concentrations in the dose-response range of the test animal. echniques designed to increase exposure concentration by heating the source, or varying product loading or source chamber air exchange alter product emissions profiles which may affect attempts to relate test animal response to human response. e designed, constructed, and determined performance characteristics for a 34-L source emissions chamber, which mates directly to a 2.3-L mouse exposure chamber and found the glass chamber to be without significant air leaks and background emissions. eversible adsorption of decane and p-dichlorobenzene was noted. t was necessary to add a fan inside the chamber.
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DESIGN AND CHARACTERIZATION OF A SMALL CHAMBER FOR CHEMICAL AND BIOLOGICAL EVALUATION OF SOURCES OF INDOOR AIR CONTAMINATION