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AIRWAY CELL AND NUCLEAR DEPTH DISTRIBUTION IN HUMAN RAT LUNGS
Citation:
Mercer, R., M. Russell, AND J. Crapo. AIRWAY CELL AND NUCLEAR DEPTH DISTRIBUTION IN HUMAN RAT LUNGS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/104 (NTIS PB92158609), 1991.
Description:
To predict the critical cells that are subject to injury from inhaled radon and other alpha particle sources it is necessary to calculate the dose absorbed by the different cells in the lungs. n order to provide information necessary to make these dose determinations, the airway epithelial thickness and the cell cytoplasm and cell nuclear volume density as a function of depth from the luminal surface of the airway epithelium were determined for the airways of human and rat lungs. he thickness of the stratified columnar epithelium of human always varied from 57.8 in bronchi to 9.8 um in bronchioles. or the human lung, the cell populations of all bronchi were comparable. at always showed significant changes in cell types between trachea and intrapulmonary always. he basal cell population In the rat trachea was similar to human bronchi and formed a nearly continuous layer. n the bronchi of the rat,, basal cells were not present In significant numbers. easurements of epithelial thickness and volume density were used to model the dose for a 1 dpm per cm2 of epithelial surface alpha particle source (Po-214) distributed uniformly in the mucous layer. he predicted doses in nGy for human bronchial epithelial cell nuclei are: Secretory 158, Preciliated 114, Ciliated 44, Goblet 86, Basal 78 and Indeterminate cell nuclei 73. redicted doses for nuclei of rat bronchial epithelium are: Secretory 237, Preciliated 216, Ciliated 203, other results indicate significant differences between human and rat airway dosimetry and may be a factor in the differences in cancer induction of the two species.
