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Workshop Background and Summary of Webinars (IVIVE workshop)
Citation:
Wambaugh, J. Workshop Background and Summary of Webinars (IVIVE workshop). Presented at In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, Research Triangle Park, NC, February 17 - 18, 2016.
Impact/Purpose:
This is an introductory talk for the National Toxicology Program's "In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making" workshop, which is being held on the U.S. EPA RTP campus. In this presentation, four introductory webinars are recapped to set the stage for the workshop's discussions.
Description:
Toxicokinetics (TK) provides a bridge between hazard and exposure by predicting tissue concentrations due to exposure. Higher throughput toxicokinetics (HTTK) appears to provide essential data to established context for in vitro bioactivity data obtained through high throughput screening. The National Toxicology Program has sponsored the workshop "In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making." In the lead-up to the meeting, a series of four webinars were held. This presentation summarizes those webinars as an introduction to the workshop. First and foremost, we must keep in mind the purpose – simple models appear to allow meaningful prioritization of further research. A primary application of HTTK is “Reverse Dosimetry” or RTK, from which we can infer daily doses that produce plasma concentrations equivalent to the bioactive concentrations identified by HTS, However, we must consider the reliability, parsimony, and domain of applicability of these approaches.