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LINDANE DOES NOT ALTER THE ESTROGEN RECEPTOR OF THE ESTROGEN-DEPENDENT INDUCTION OF PROGESTERONE RECEPTORS IN SEXUALLY IMMATURE OR OVARIECTOMIZED ADULT RATS
Citation:
Laws, S., S. Carey, AND R. Cooper. LINDANE DOES NOT ALTER THE ESTROGEN RECEPTOR OF THE ESTROGEN-DEPENDENT INDUCTION OF PROGESTERONE RECEPTORS IN SEXUALLY IMMATURE OR OVARIECTOMIZED ADULT RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/215, 1994.
Description:
Lindane, Y-1,2,3,4,5,6-hexachlorocyclohexane (Y-HCH), has been shown to disrupt reproductive function in mammals. Many of these adverse effects on female reproduction such as alterations in sexual receptivity, disrupted ovarian cyclicity, reduction in uterine weight and termination of pregnancy are thought to be due to altered ovarian hormone secretions and/or an impaired response in circulating estrogen. t has been suggested that Y-HCH may block the response of estrogen-dependent tissues to estradiol via an interaction with the estrogen receptor. o test this hypothesis, estrogen (ER) and progesterone (PR) receptor affinity and number were evaluated in sexually immature, EB primed Long Evans female rats following exposure to vehicle or Y-HCH (40 mg/kg) for 7 days (Study 1) and in adult, ovariectomized EB-primed Long-Evans rats following gavage with vehicle or Y-HCH (0,10,20, or 40 mg/kg) for 5 days (Study 2). hlordecone (Kepone; 40 mg/kg; s.c.) was used in Study 1 as a positive control for the alteration of the estrogen-induction of PR in the pituitary. Neither Y-HCH nor chlordecone altered serum estradiol concentrations. -HCH did notchange the number of ER (1, 24, or 30 hrs after EB) or the estrogen-dependent induction of PR (24 or 48h after EB) in the hypothalamus (HYP), pituitary, or uterus. hese data indicate that the effects off-HCH on the female reproductive system do not involve an alteration in the ER. hlordecone significantly reduced the estrogen-dependent induction of PR in the pituitary, but had no effect in the HYP or uterus. hese data also show that heterogeneity exists between target tissues in their response to xenobiotics.