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Developing and applying adverse outcome pathways: What you need to know
Citation:
Villeneuve, Dan, S. Edwards, AND D. Martinovic-Weigelt. Developing and applying adverse outcome pathways: What you need to know. SETAC North America, Salt Lake City, UT, November 01 - 05, 2015.
Impact/Purpose:
Not Applicable
Description:
Adverse outcome pathways (AOPs) are a conceptual framework for organizing existing information concerning the predictive linkages between the initiation or early progression of a biological perturbation in an organism and the adverse outcome(s) of regulatory relevance (e.g., impacts on survival, growth, or reproduction) that the perturbation can lead to. Consequently, the organization of biological and toxicological knowledge into AOP frameworks has been advocated as a means to support so called “21st century” approaches to regulatory decision-making which aim to make greater use of high throughput pathway-based data as a basis for chemical safety assessment. In order to facilitate the development of AOPs and their practical application to environmental decision-making the Organization for Economic Cooperation and Development (OECD), through the activities of its member countries, has developed internationally harmonized guidance and a knowledge-base for capturing and disseminating AOP descriptions. The training provided as part of this short course is intended to facilitate greater awareness the adverse outcome pathway knowledgebase and associated guidance, principles, and practice of AOP development and description, so that the scientific community can more effectively contribute to and utilize this emerging resource.