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USING NEUROBLASTOMA CELL LINES TO EXAMINE ORGANOPHOSPHATE NEUROTOXICITY
Citation:
Veronesi, B., M. Ehrich, AND A. Nostrandt. USING NEUROBLASTOMA CELL LINES TO EXAMINE ORGANOPHOSPHATE NEUROTOXICITY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/332 (NTIS PB93229508), 1993.
Description:
The need to deploy IN VITRO models to test neurotoxic scribes the use of by industry and government regulatory agencies. his research describes the neuroblastoma cell lines to address the relationship between esterase inhibition and neurotoxic outcome following exposure to organophosphate pesticides. his study as evaluated various commercially available cell lines for their target esterase levels, variety of organophosphates, has established dose-response cytotoxicity data between related cytotoxicity with rodent LD50 data, and has used cells to distinguish neuropathy-causing (OPIDN) pesticides from cholinesterase inhibitors. hese preliminary data support the use of cell lines as effective test models for organophosphate neurotoxicity.