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Computer Simulation of Embryonic Systems: What can a virtual embryo teach us about developmental toxicity? (LA Conference on Computational Biology & Bioinformatics)
Citation:
Knudsen, T. Computer Simulation of Embryonic Systems: What can a virtual embryo teach us about developmental toxicity? (LA Conference on Computational Biology & Bioinformatics). 4th Annual LA Conference on Computational Biology & Bioinformatics, New Orleans, LA, April 01 - 02, 2016. https://doi.org/10.23645/epacomptox.5077609
Impact/Purpose:
This invited presentation is a keynote lecture at the 4th Annual LA Conference on Computational Biology & Bioinformatics.
Description:
This presentation will cover work at EPA under the CSS program for: (1) Virtual Tissue Models built from the known biology of an embryological system and structured to recapitulate key cell signals and responses; (2) running the models with real (in vitro) or synthetic (in silico) data can be used to predict emergent responses to perturbation; (3) simulated outcomes can be validated against experimental phenotypes to assess model performance and analyze sensitivity; and (4) models can help translate screening-level data from chemical-biology into predictive toxicology of a developmental hazard.
URLs/Downloads:
DOI: Computer Simulation of Embryonic Systems: What can a virtual embryo teach us about developmental toxicity? (LA Conference on Computational Biology & Bioinformatics)
KNUDSEN_LA_COMPBIO_2016.PDF (PDF, NA pp, 5449.363 KB, about PDF)