You are here:
HYPERACTIVITY AND HYPOACTIVITY PRODUCED BY LESIONS TO THE MESOLIMBIC DOPAMINE SYSTEM
Citation:
Koob, G., L. Stinus, AND M. Moal. HYPERACTIVITY AND HYPOACTIVITY PRODUCED BY LESIONS TO THE MESOLIMBIC DOPAMINE SYSTEM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/579 (NTIS PB82248014), 1981.
Description:
Spontaneous locomotor activity and the locomotor response to amphetamine and apomorphine were studied in rats subjected to either radiofrequency(RF), 6-hydroxydopamine (6-OHDA) of both RF and 6-OHDA lesions of the mesolimbic dopamine (DA) system. Large 6-OHDA lesions of the ventral tegmental area (VTA) or of the nucleus accumbens (N.Acc) produced hypo-activity in the open field, a complete blockade of the locomotor stimulating effects of D-amphetamine, and a profound supersensitive response to apomorphine as measured by a significant increase in locomotor activity as compared to sham-operated animals.