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COMPARISON OF THE RELATIVE INHIBITION OF ACETYLCHOLINESTERASE AND NEUROPATHY TARGET ESTERASE IN RATS AND HENS GIVEN CHOLINESTERASE INHIBITORS
Citation:
Ehrich, M., B. Jortner, AND S. Padilla. COMPARISON OF THE RELATIVE INHIBITION OF ACETYLCHOLINESTERASE AND NEUROPATHY TARGET ESTERASE IN RATS AND HENS GIVEN CHOLINESTERASE INHIBITORS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/155, 1995.
Description:
Inhibition of neuropathy target esterase (NTE, neurotoxic esterase) and acetylcholinesterase (AME) activities was compared in brain and spinal cords of adult. hile Leghorn hens and adult male Long Evans rats 4-48 hr after administration of tri-ortho-tolyl phosphate (TOTP po, 50-500 mg/kg to hens; 300-1000 mg/kg to rats), phenyl saligenin phosphate (PSP im.0.1-2.5 mg/kg to hens; 5-24 mg/kg to rats), mipafox (3-30 mg/kg ip to hens and rats), diisopropyl phosphorofluoridate (DFP sc, 0.25-1.0 mg/ kg to hens; 1-3 mg/kg to rats), dichlorvos (5-60 mg/kg ip to hens; 600-2000 mg/kg to rats), malathim (75-300mg/kg po to hens; 600-2000 mg/kg to rats), and carbaryl (300-560 ng/kg ip to hens; 30-170 mg/kg to rats). nhibition of NTE and ACHE were dose-related ,after administration of all compounds to both species. ens and rats given TOTP, PSP, mipafox, and DFP demonstrated delayed neuropathy 3 weeks later, with spinal cord lesion and clinical signs more notable in hens. atios of NTE/ACHE inhibition in hen spinal cord, averaged over the doses used, were 2.6 after TOTP, 5.2 after PSP, 1.3 after mipafox, and 0.9 after DFP, which contrast with 0.53 after dichlorvos, 1.0 after malathion, and 0.46 after carbaryl. at NTE/ACHE inhibition ratios were 0.9 after TOTP, 2.6 after PSP, 1.0 after mipafox, 0.62 after DFP, 1.3 after dichlorvos, 2.2 after malathion, and 1.1 after carbaryl- The lower NTE/ACHE ratios in rats given dosages of the four organophosphorus compounds that caused delayed neuropathy interfered with survival, an effect that was not a problem in hens.