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ORGAN AND SPECIES SPECIFICITY IN CHEMICAL CARCINOGENESIS
Citation:
Langenbach, R., S. Nesnow, AND J. Rice. ORGAN AND SPECIES SPECIFICITY IN CHEMICAL CARCINOGENESIS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/9-83/008 (NTIS PB83220137), 1983.
Description:
The focus of the Symposium and this volume is the relative susceptibility of specific animal species strains and organs to various carcinogens. For the first time, investigators in chemical carcinogenesis are able to pool their discoveries in this area. Once analyzed, this data could substantially contribute to man's understanding of potential carcinogens and their human health effects and increase the possibility of cancer prevention. The thirty-five papers fall into six general areas: comparative effects of chemical carcinogens, promoting agents, metabolism as a determinant of organ specificity, species and organ specificity as studied by in vitro techniques, DNA damage and repair, and risk extrapolation. Discussion generated by the presentations are also included.