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QEEN Workshop: "Quantifying Exposure to Engineered Nano-materials from Manufactured Products": Write Up Biological Tissues and Media
Citation:
Boyes, W. AND E. Petersen. QEEN Workshop: "Quantifying Exposure to Engineered Nano-materials from Manufactured Products": Write Up Biological Tissues and Media. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-15/241, 2016.
Impact/Purpose:
QEEN Workshop: "Quantifying Exposure to Engineered Nano-materials from Manufactured Products". This is only one section of the meeting report covering a session chaired by the authors
Description:
The measurement and characterization of nanomaterials in biological tissues is complicated by a number of factors including: the sensitivity of the assay to small sized particles or low concentrations of materials; the ability to distinguish different forms and transformations of the materials related to the biological matrix; distinguishing exogenous nanomaterials, which may be composed of biologically common elements such as carbon,from normal biological tissues; differentiating particle from ionic phases for materials that dissolve; localization of sparsely distributed materials in a complex substrate (the "needle in the haystack" problem); and a plethora of potential artifacts of analysis. In thisbreakout session,four speakers discussed the current state-of-the-art with regards to quantifying the exposure concentration of nanoparticles (NPs) in biological tissues and biological media. Importantly, the media ranged from concentrations in organism tissues using microscopic measurements to the mass concentration of nanoparticles in synthetic stomach fluid, a surrogate media to assess changes to nanoparticles after ingestion by humans.
