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DISTRIBUTION OF ORALLY ADMINISTERED CHRYSOTILE ASBESTOS IN NEWBORN BABOON BODY
Citation:
Patel-Mandlik, K. DISTRIBUTION OF ORALLY ADMINISTERED CHRYSOTILE ASBESTOS IN NEWBORN BABOON BODY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/1-80/022.
Description:
This report presents the results of transmission electron microscopic analyses for asbestos in ten organs of the newborn baboon which was orally administered chrysotile asbestos. The feeding period consisted of nine days with a cumulative dose of 3 x10 to the 13th power chrysotile fibers per kilogram. Analyses of the same ten organs of a control newborn baboon is also included. The test tissues showed higher levels of asbestos than respective control tissues. The highest concentration of chrysotile fibers was found in the kidney cortex followed by lymph nodes, spleen, colon, esophagus, kidney medulla, stomach, and liver. Fiber size distribution of the fibers recovered from all organs is presented.