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Exposure Space: Integrating Exposure Data and Modeling with Toxicity Information
Citation:
Vallero, D. Exposure Space: Integrating Exposure Data and Modeling with Toxicity Information. OpenTox Conference, Baltimore, MD, Baltimore, MD, February 10 - 12, 2015.
Impact/Purpose:
The National Exposure Research Laboratory (NERL) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA mission to protect human health and the environment. HEASD research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.
Description:
Recent advances have been made in high-throughput (HTP) toxicity testing, e.g. from ToxCast, which will ultimately be combined with HTP predictions of exposure potential to support next-generation chemical safety assessment. Rapid exposure methods are essential in selecting chemicals for 1) targeted toxicity testing, 2) higher-tier exposure assessments, and 3) biomonitoring studies. Unfortunately, for the majority of chemicals in Phase II of ToxCast and beyond (i.e., non-pesticide environmental compounds) there are no available estimates of exposure. Therefore, the U.S. EPA is developing scientifically-defensible HTP methods for developing quantitative or semi-quantitative exposure predictions, analogous to HTP toxicity methods. This session will discuss advances in exposure modeling and informatics, including SHEDS-HT, ExPriori (dose ranking), computational exposure sciences (including chemical and exposure space principal components), and new product-use data sources.
