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ACUTE METHANOL TOXICITY IN MINIPIGS
Citation:
Dye, J., D. Dorman, M. Nassise, J. Ekuta, B. Bolon, AND M. Medinsky. ACUTE METHANOL TOXICITY IN MINIPIGS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-94/392 (NTIS PB95126520).
Description:
The pig hos been proposed as a potential animal model for methanol-induced neuro-ocular toxicosis in humans because of its reported low liver tetrahydro folate levels and therefore, slower formate metabolism as compared to humans. o determine the validity of the animal model, minipigs were given a single oral dose of methanol or water. ose-dependent signs developed including mild CNS depression, tremers, and ataxia, however, these subjects failed to develop optic nerve lesions, toxicologically-significant formate accumulation or metabolic acidosis. ethanol and formate pharmacokinetics are also discussed.