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In Vitro Assessment of Gamete Integrity
Citation:
Perreault, S. D. In Vitro Assessment of Gamete Integrity. Chapter D1, Alan M. Goldberg (ed.), AIn Vitro Toxicology: Mechanisms and New Technology. Mary Ann Liebert, Inc., Larchmont, NY, 8:63-75, (1991).
Impact/Purpose:
To show recent advances in in vitro technologies for assessing both the pathophysiologic and genetic integrity of gametes.
Description:
Drug and xenobiotics can compromise reproductive function by impairing gamete physiology and thereby blocking fertilization, or by damaging gamete DNA or chromatin and thereby causing pregnancy failure or birth defects. tandard measures of gamete integrity, such as morphology, motility (sperm), or fertilizing ability, while useful in identifying and characterizing adverse effects, may not identify genetic damage in the gametes. o better assess gamete integrity, methods capable of detecting DNA or chromosomal damage in individual sperm or egg cells are needed. his report summarizes recent advances in in vitro technologies for assessing both the pathophysiologic and genetic integrity of gametes with emphasis on the latter.
