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PULMONARY EFFECTS DUE TO SUBCHRONIC EXPOSURE TO OIL FOG
Citation:
Selgrade, M., G. Hatch, E. Grose, A. Stead, F. Miller, J. Graham, M. Stevens, AND J. Hardisty. PULMONARY EFFECTS DUE TO SUBCHRONIC EXPOSURE TO OIL FOG. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/080 (NTIS PB90245465).
Description:
Male rats were exposed to an oil fog generated by flash vaporization and subsequent condensation of lightweight lubricating oil. Exposures were for 3.5 h/d, 4d/wk for 13 wk, at concentrations of 1.5, 0.5, 0.2 or 0.0 mg/l (1500, 500, 200, and 0 mg/m3) and a particle size of approximately 1 um (mass median aerodynamic diameter). umber of biologic endpoints were assessed the day after the last exposure and, in some cases, after a 4 wk recovery period. ffects of 1.5 mg/l on male and female rats were compared. iffuse accumulation of macrophages in the alveoli was observed in all oil fog exposed groups. he degree of severity was concentration dependent. istopathologic changes were more prominent in males than in females and represented the most notable gender-related differences. istologic effects observed one day and 4 wk post exposure were similar. inimal histopathologic changes and minimal increase in lavage fluid protein were the only effects observed at the 0.2 mg/l exposure level. here was a significant increase in lavage fluid protein, percent lavagable polymorphonuclear leukocytes and lung wet and dry weight following exposure to both 0.5 and 1.5 mg/l. t the highest exposure concentration effects on lung weights were still evident 4 wk post exposure. ulmonary function endpoints including total lung capacity, vital capacity, residual olume, diffusing capacity to CO, compliance, and end expiratory volume (EEV) were unaffected by oil fog exposure with the exception of EEV in males exposed at the 1.5 mg/l level. ll of the changes observed following oil fog exposure were consistent with a mild inflammatory edema.