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Adverse Outcome Pathways: From Research to Regulation - Scientific Workshop Report
Citation:
Kleinstreuer, N., K. Sullivan, D. Allen, S. Edwards, D. Mendrick, M. Embry, J. Matheson, J. Rowlands, S. Munn, E. Maull, AND W. Casey. Adverse Outcome Pathways: From Research to Regulation - Scientific Workshop Report. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 76:39-50, (2016).
Impact/Purpose:
This manuscript provides a summary of a workshop that took place in September 2014. The discussions at this workshop have added to the consensus building within the field of AOPs and helped to shape the direction of the field.
Description:
An adverse outcome pathway (AOP) organizes existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductive impairment. AOPs can help identify knowledge gaps where more research is needed to understand the underlying mechanisms, aid in chemical hazard characterization, and guide the development of new testing approaches that use fewer or no animals. A September 2014 workshop co-sponsored by NICEATM and PCRM considered how the AOP concept could improve regulatory assessments of chemical toxicity. Scientists from 21 countries, representing industry, academia, regulatory agencies, and special interest groups, attended the workshop, titled Adverse Outcome Pathways: From Research to Regulation. Workshop plenary presentations were followed by breakout sessions that considered regulatory acceptance of AOPs and AOP-based tools, criteria for building confidence in an AOP for regulatory use, and requirements to build quantitative AOPs and AOP networks. Discussions during the closing session emphasized a need to increase transparent and inclusive collaboration, especially with disciplines outside of toxicology. Additionally, to increase impact, working groups should be established to systematically prioritize and develop AOPs. Multiple collaborative projects and follow-up activities resulted from the workshop.
