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High Throughput Assays and Exposure Science (ISES annual meeting)
Citation:
Wambaugh, J. High Throughput Assays and Exposure Science (ISES annual meeting). Presented at International Society for Exposure Science annual Meeting, Henderson, NV, October 18 - 22, 2015. https://doi.org/10.23645/epacomptox.5067700
Impact/Purpose:
This is a presentation to the International Science for Exposure science annual meeting. This presentation is part of a symposium entitled "Evolving Analytical Methods". The goal of the presentation is to motivate and describe the ongoing ExpoCast contract research.
Description:
High throughput screening (HTS) data characterizing chemical-induced biological activity has been generated for thousands of environmentally-relevant chemicals by the US inter-agency Tox21 and the US EPA ToxCast programs. For a limited set of chemicals, bioactive concentrations related to over 700 diverse assay endpoints can be directly integrated with ongoing exposure biomonitoring programs, such as the blood and serum chemical concentration datasets generated by the US Centers for Disease Control National Health and Nutrition Survey. In most cases, however, the data needed to compare bioactivity from HTS with relevant human exposures does not exist. The EPA’s ExpoCast program is developing high throughput approaches to generate exposure estimates using existing databases and new, high throughput measurements including physico-chemical properties, concentrations in consumer products, and non-targeted monitoring for occurrence in environmental and biological samples. These exposure estimates are critical in developing rapid and cost-effective testing priorities for thousands of chemicals that currently lack hazard and exposure data. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: High Throughput Assays and Exposure Science (ISES annual meeting)
ISES-2015-WAMBAUGH-2.PDF (PDF, NA pp, 1059.998 KB, about PDF)