You are here:
R Package - httk (Syngenta webinar)
Citation:
Wambaugh, J. R Package - httk (Syngenta webinar). Presented at webinar presentation to Syngenta, Research Triangle Park, NC, August 05, 2015. https://doi.org/10.23645/epacomptox.5077921
Impact/Purpose:
This is a webinar presentation to Syngenta describing the use of the R software tool ("httk") developed by the Rapid Exposure and Dosimtery project for high throughput toxicokinetics, including reverse dosimetry.
Description:
Functions and data tables for simulation and statistical analysis of chemical toxicokinetics ("TK") using data obtained from relatively high throughput, in vitro studies. Both physiologically-based ("PBTK") and empirical (e.g., one compartment) "TK" models can be parameterized for several hundred chemicals and multiple species. These models are solved efficiently, often using compiled (C-based) code. A Monte Carlo sampler is included for simulating biological variability and measurement limitations. Functions are also provided for exporting "PBTK" models to "SBML" and "JARNAC" for use with other simulation software. These functions and data provide a set of tools for in vitro-in vivo extrapolation ("IVIVE") of high throughput screening data (e.g., ToxCast) to real-world exposures via reverse dosimetry (also known as "RTK").
URLs/Downloads:
DOI: R Package - httk (Syngenta webinar)
WAMBAUGH SYNGENTA-HTTK WEBINAR.PDF (PDF, NA pp, 1764.984 KB, about PDF)