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THYROID CANCER RISK FROM EXPOSURE TO IONIZING RADIATION: A CASE STUDY IN THE COMPARATIVE POTENCY MODEL
Citation:
Laird, N. THYROID CANCER RISK FROM EXPOSURE TO IONIZING RADIATION: A CASE STUDY IN THE COMPARATIVE POTENCY MODEL. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-87/519.
Description:
Considerable controversy exists about the relative risk of thyroid cancer following exposure to external radiation compared to the risk after exposure to internally deposited 131I. he human epidemiological data are equivocal, and studies are not directly comparable owing to differing ages at exposure, dose ranges, and periods of follow-up. imited experimental data at low dose ranges support the hypothesis of equal potency in animals. his report utilizes a relative potency model to reconcile data from different sources, and to provide an estimate of thyroid cancer risk following human exposure to 131I. e utilize data from epidemiological studies of external radiation and 131I exposure in humans and data from an experimental animal study. his analysis shows that the data provide no compelling evidence to suggest that the risks accompanying external radiation or l3lI exposure are different.