You are here:
Repeated measures of inflammation, blood pressure, and heart rate variability associated with personal traffic exposures in healthy adults
Citation:
Mirowsky, J., R. Peltier, M. Lippmann, G. Thurston, L. Neas, D. Diaz-Sanchez, R. Laumbach, AND T. Gordon. Repeated measures of inflammation, blood pressure, and heart rate variability associated with personal traffic exposures in healthy adults. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, 14(1):66, (2015).
Impact/Purpose:
This manuscript addresses the human health impacts of acute exposures to traffic in an adult panel study. These results are a major contribution towards the completion of ACE Task 034.
Description:
BACKGROUND: Previous human exposure studies of traffic-related air pollutants have demonstrated adverse health effects in human populations by comparing areas of high and low traffic, but few studies have utilized microenvironmental monitoring of pollutants at multiple traffic locations while looking at a vast array of health endpoints in the same population. We evaluated inflammatory markers, heart rate variablity (HRV), blood pressure,exhaled nitric oxide, and lung function in healthy participants after exposures to varying mixtures of traffic pollutants.METHODS:A repeated-measures, crossover study design was used in which 23 healthy, non smoking adults had clinical cardiopulmonary and systemic inflammatory measurements taken prior to, immediately after, and 24 hours after intermittent walking for two hours in the summer months along three diverse roadways having unique emission characteristics. Measurements of PM2.5, PM10, black carbon (BC), elemental carbon (EC), and organic carbon (OC) were collected. Mixed effect models were used to assess changes in health effects associated with these specific pollutant classes.RESULTS: Minimal associations were observed with lung function measurements and the pollutants measured. Small decreases in BP measurements and rMSSD, and increases in IL-1B and the low frequency to high frequency ratio measured in HRV, were observed with increasing concentrations of PM2.5 EC.CONCLUSIONS: Small, acute changes in cardiovascular and inflammation-related effects of microenvironmental exposures to traffic-related air polution were observed in a group of healthy young adults. The associations were most profound with the diesel-source EC.
