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INTERSPECIES COMPARISONS OF BENZO(A)PYRENE METABOLISM AND DNA-ADDUCT FORMATION IN CULTURED HUMAN AND ANIMAL BLADDER AND TRACHEOBRONCHIAL TISSUES
Citation:
Daniel, F., H. Schut, D. Sandwisch, K. Schenck, AND C. Hoffmann. INTERSPECIES COMPARISONS OF BENZO(A)PYRENE METABOLISM AND DNA-ADDUCT FORMATION IN CULTURED HUMAN AND ANIMAL BLADDER AND TRACHEOBRONCHIAL TISSUES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J--8//240.
Description:
Cultured bladder and tracheobronchial explants from human, monkey, dog, hamster, and rat were used to study the metabolism, covalent binding to DNA, and DNA:adduct formation of (3H0benzo(a)pyrene (BP). Both organs from all species formed large amounts (40 to 70% of total 3H in the medium after 24 hr of incubation) of polar material and small amounts (<1% for animal tissues and 1 to 5% for human tissues) of organic solvent-extractable (unconjugated) metabolites, with the balance (14 to 38%) being unmetabolized BP.