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CHEMICAL EXPOSURES AND ANIMAL ACTIVITY: UTILITY OF THE FIGURE-EIGHT MAZE
Citation:
Reiter, L.W. CHEMICAL EXPOSURES AND ANIMAL ACTIVITY: UTILITY OF THE FIGURE-EIGHT MAZE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-84/011 (NTIS PB84145176).
Description:
The need for rapid and inexpensive tests in toxicology has prompted several advisory panels to recommend motor activity as a screen for neurotoxicity. Since motor activity reflects the general status of the organism, disruption produced by a variety of neurotoxic and non-neurotoxic mechanisms should be manifest as changes in motor activity. Studies of motor activity are useful, therefore, when no a priori reason exists for predicting a particular behavioral effect of exposure to a chemical. Activity measurements are also useful in characterizing the toxic properties of a chemical.