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EPA Exposure Research and the ExpoCast Project: New Methods and New Data (NIEHS Exposome webinar)
Citation:
Wambaugh, J. EPA Exposure Research and the ExpoCast Project: New Methods and New Data (NIEHS Exposome webinar). Presented at NIEHS Exposure Science & the Exposome webinar, Research Triangle Park, NC, May 14, 2015.
Impact/Purpose:
Webinar presentation for NIEHS Exposure Science & the Exposome webinar series. The presentation focusing on the relationship between CSS Rapid Exposure and Dosimetry research and the Exposome with an emphasis on motivating the new ExpoCast data contracts.
Description:
Estimates of human and ecological exposures are required as critical input to risk-based prioritization and screening of thousands of chemicals. In a 2009 commentary in Environmental Health Perspectives, Shelden and Hubal proposed that “Novel statistical and informatic approaches should be applied to extant exposure data to facilitate the identifica¬tion of critical metrics that represent personal exposure through time, place, life stage, life¬style, or behavior.” The Rapid Exposure and Dosimetry project within the U.S. E.P.A.’s Chemical Safety for Sustainability research program provides a portfolio of research that supports and advances what is colloquially known as the “ExpoCast” project. This project seeks to develop the data, tools, and evaluation approaches required to generate rapid and scientifically-defensible exposure predictions for the full universe of existing and proposed commercial chemicals. In addition to applying appropriate statistical techniques to use existing data sources in new ways, ExpoCast contracts have been awarded to provide new types of data allowing better prediction of exposure to chemicals through the environment. A key application of this new suite of data and tools may be the identification of xenobiotic substances indicated by non-targeted screening for chemicals.