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Blood Metal Concentrations of Manganese, Lead, and Cadmium in Relation to Serum Ferritin Levels in Ohio Residents
Citation:
Kim, Y., D. Lobdell, V. Gocheva, E. Hudgens, R. Bowler, AND C. Wright. Blood Metal Concentrations of Manganese, Lead, and Cadmium in Relation to Serum Ferritin Levels in Ohio Residents. Biological Trace Element Research. Springer, New York, NY, 165(1):1-9, (2015).
Impact/Purpose:
This study addresses research questions under Sustainable and Healthy Communities (2.2.1.6 lessons learned, best practices and stakeholder feedback from community and tribal participative case studies). This Regional Applied Research Effort project is a joint effort between Region 5 and ORD Scientists that examined neurotoxic effects of Mn within two communities: a high level air exposure community (East Liverpool, Ohio) and a mid to low range air exposure community (Marietta, Ohio). This work is important in that either positive results (differences between the high level air Mn exposure community and comparison communities) or negative results (little or no differences among communities) inform the issue of potential health effects of residential airborne Mn exposure, a recognized gap in Mn health effects literature. Both outcomes can also help inform the need for greater airborne Mn control. The present study is a methodological study looking at metal biomarkers and ferritin levels in this study population. - Note:Title was modified for publication from: Ferritin-specific profiles of blood metal concentrations in Ohio residents. per Dr. Hudgens
Description:
The objectives of this study were to assess fcrritin-specific profiles of blood metal concentrations such as manganese, lead, and cadmium and to evaluate whether ferritin may affect the behavior of the blood metals in relation to menstruation, menopause, or sex in Ohio residents. Recruited paticipants included residents from Marietta, East Liverpool, and Mt. Vernon, OH, USA, who were aged 30-75 years and lived at least 10 years in their respective town. The levels of the neurotoxic metals such as manganese, cadmium, and lead were assayed in whole blood. Serum was analyzed for ferritin level [as a biomarker of iron (Fe) status]. An association between blood metal concentrations and independent variables (age, serum ferritin, manganese exposure status, and sex) by multiple regression analysis was assessed, controlling for various covariates such as BMI, educational level, smoking, and alcohol drinking status. Overall, the geometric means of blood manganese, cadmium, and lead levels of all participants (n = 276) were 9.307 µg/L, 0.393 µg/L, and 1.276 µg/dL, respectively. Log serum ferritin concentrations were inversely associated with log blood manganese concentration (B = -0.061 log ferritin and B = 0.146 categorical ferritin) and log blood cadmium concentrations (B = -0.090 log ferritin and B = 0.256 categorical ferritin). Log serum ferritin concentrations were not associated with log blood lead concentrations. Variables of age, sex, and exposure status were not associated with log manganese concentrations: however, log blood cadmium concentrations were higher in older population, women, and smokers. Log blood lead concentrations were higher in older population, men, and postmenopausal women. Our study showed that iron deficiency is associated with increased levels of blood manganese and cadmium, but not blood lead, in Ohio residents. These metals showed different toxicokinetics in relation to age, sex, and menopausal status despite similar relationships between ferritin and metal concentrations.
