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Ferrate promoted oxidative cleavage of sulfonamides: Kinetics and product formation under acidic conditions
Citation:
Sharma, V., C. Kim, P. Gardinali, R. Varma, AND H. Kim. Ferrate promoted oxidative cleavage of sulfonamides: Kinetics and product formation under acidic conditions. Chemical Engineering Journal. Elsevier BV, AMSTERDAM, Netherlands, 279:307-316, (2015).
Impact/Purpose:
Submitted for publication in Chemical Engineering Journal.
Description:
Sulfonamide-based antibiotics are often detected in surface waters and secondary wastewater effluents and pose an eminent threat for the development of antibiotic resistance bacteria and genes in aquatic environment. This paper presents the kinetics and stoichiometry of the oxidation of sulfonamides (sulfaguanidine, sulfisoxazole, sulfamethizole, sulfamethoxazole (SMX), sulfamethizine, and sulfadimethoxine) by ferrate(VI) (FeO42-, Fe(VI)) in the acidic to basic pH range (2.0-9.6); apparent second-order rate constants (kapp, M-1 s-1) decreased non-linearly with increase in pH. The specific rate constants for the individual Fe(VI) species (H3FeO4+, H2FeO4, HFeO4-, and FeO4-) were determined using acid-base equilibria of Fe(VI) and sulfonamides. The reactivity order of Fe(VI) species with the neutral sulfonamide was H3FeO4+ > H2FeO4 > HFeO4-, which generally explained the pH dependence behavior of rate constants. Detailed studies regarding the resultant oxidized products (OPs) using liquid chromatography-mass spectrometry/mass spectrometry were performed for oxidation of SMX at different molar ratios of Fe(VI) to SMX (i.e., 1.0-15) and at different pH’s (i.e., 4.0, 7.0, and 9.0); oxidative degradative products include 3-amino-5-methylisoxazole, and hydroxyl-, hydroxylamine-, nitroso-, and nitro- derivatives of SMX. The possible reaction pathways comprise the S-N bond cleavage, ring-opening of isoxazole moiety, oxidation of aromatic amine, and the hydroxylation of the benzene ring; different OPs formed under acidic, neutral, and basic pH conditions are described. The value of kapp, 8.9 × 102 M-1 s-1 at pH 7.0 suggests the oxidative transformation of SMX in seconds by 1 mg L-1 K2FeO4 and interestingly, the removal of SMX could be achieved in the presence of humic acid at neutral pH by Fe(VI).
