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IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Discussion Draft)
Citation:
U.S. EPA. IRIS Toxicological Review of Trimethylbenzenes (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-16/001, 2016.
Impact/Purpose:
EPA is reassessing its IRIS toxicological review of Trimethylbenzenes (1,2,3-;1,2,4-;1,3,5-). This trimethylbenzene reassessment consists of an oral reference dose (RfD), an inhalation reference concentration (RfC), an inhalation unit risk (IUR) and a cancer weight of evidence descriptor. This is the first assessment developing an RfC or IUR for this compound. This assessment is intended to provide human health data to support agency regulatory decisions.
Description:
In September 2016, EPA finalized the IRIS assessment of Trimethylbenzenes. The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices before public release in June 2016. Consistent with the May 2009 IRIS assessment development process, all written comments on IRIS assessments submitted by other federal agencies and White House Offices are made publicly available. Accordingly, interagency comments and the interagency science discussion materials provided to other agencies, including interagency review drafts of the IRIS Toxicological Review of Trimethylbenzenes are posted on this site.
URLs/Downloads:
IRIS Toxicological Review of Trimethylbenzes (Interagency Science Discussion Draft) (PDF, 148 pp, 2484 KB, about PDF)IRIS Toxicological Review of Trimethylbenzes (Interagency Science Discussion Draft) -- Supplemental Information (PDF, 353 pp, 10098 KB, about PDF)
EPA's Response to select Interagency Science Discussion Comments (PDF, 2 pp, 123 KB, about PDF)
1. DoD Comments on Trimethylbenzenes (PDF, 8 pp, 65 KB, about PDF)
2. OMB Email Comments on Trimethylbenzenes (PDF, 1 pp, 196 KB, about PDF)
3. OMB Comments on Trimethylbenzenes (PDF, 1 pp, 167 KB, about PDF)
4. SBA Comments on Trimethylbenzenes (PDF, 4 pp, 709 KB, about PDF)