Citation:

Wambaugh, J. Exposure Pathways, Biomarkers and the Exposome: Predictions, Insight, and Uncertainty (SOT presentation - CE lecture). Presented at Society of Toxicology, San Diego, CA, March 22 - 26, 2015. https://doi.org/10.23645/epacomptox.5082784

Impact/Purpose:

This presentation is a one hour lecture as part of a Society of Toxicology Continuing Education Course entitled "An Introduction to the Exposome." The course will be taught on Sunday, March 22, 2015 in San Diego, CA The agenda is: 8:20 AM—9:10 AM The Exposome: Introduction and Implications for Toxicology Gary W. Miller Emory University 9:10 AM—10:00 AM Exposure Pathways, Biomarkers and the Exposome: Predictions, Insight, and Uncertainty John F. Wambaugh US EPA 10:00 AM—10:30 AM BREAK 10:30 AM—11:15 AM The Blood Exposome Martyn T. Smith University of California Berkeley 11:15 AM—12:00 Noon Exposome Bioinformatics: EWAS and Beyond Chirag J. Patel Harvard Medical School

Description:

The risk posed to human health by any of the thousands of untested anthropogenic chemicals in our environment is a function of both the hazard presented by the chemical and the extent of exposure. However, many chemicals lack estimates of exposure intake, limiting the understanding of health risks. We describe tools for determining potential human exposure and how those tools are calibrated using reverse dosimetry to infer exposures from biomarkers identified in urine samples from the U.S. population by the National Health and Nutrition Examination Survey (NHANES). For thousands of chemicals with no other information, this approach allows forecasting of average exposure intake of environmental chemicals.

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