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Chapter 22: Female Reproductive Toxicology
Citation:
Goldman, J. AND R. Cooper. Chapter 22: Female Reproductive Toxicology. Chapter 22, Mohamed Abou-Donia (ed.), Mammalian Toxicology. John Wiley & Sons, Inc, Hoboken, NJ, 1:493-496, (2015).
Impact/Purpose:
This chapter (Female Reproductive Toxicology) is a comprehensive review of female reproductive toxicology that will become part of an inclusive text on Mammalian Toxicology to be published by John Wiley & Sons. According to the editor, its target audience is advanced undergraduates, graduates and post-graduates in toxicology. Secondarily, the book is intended to be a resource for those in academia, industry, and government.
Description:
The female reproductive system provides multiple targets for environmental toxicants with the hypothalamic-pituitary-ovarian axis. Moreover, the functional impact of a chemical can differ, depending on the species involved and the parameters of exposure. While cross-species comparisons are provided for a number of mammalian reproductive strategies, the principal focus is on the rodent's response to chemical insult, given that this species has been employed extensively for testing within regulatory guidelines established as requisite for registration of pesticides and industrial chemicals by both the U.S. Environmental Protection Agency and the Organization of Economic Cooperation and Development (OECD). A wide-ranging presentation of toxicological responses in the developing female and adult is presented against a backdrop of female reproductive physiology and endocrinology.