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Test driving ToxCast: endocrine profiling for1858 chemicals included in phase II
Citation:
Filer, D., H. Patisaul, T. Schug, D. Reif, AND K. Thayer. Test driving ToxCast: endocrine profiling for1858 chemicals included in phase II. Current Opinion in Pharmacology. Elsevier B.V., Amsterdam, Netherlands, 19(12):145-152, (2014).
Impact/Purpose:
Identifying chemicals to test for potential endocrine disruption beyond those already implicated in the peer-reviewed literature is a challenge. This review is intended to help by summarizing findings from the Environmental Protection Agency’s (EPA) ToxCast™ high throughput in vitro screening (HTS) program.
Description:
Introduction: Identifying chemicals to test for potential endocrine disruption beyond those already implicated in the peer-reviewed literature is a challenge. This review is intended to help by summarizing findings from the Environmental Protection Agency’s (EPA) ToxCast™ high throughput in vitro screening (HTS) program. Methods: We updated the previously published ToxPi™ model for endocrine disruption, expanding the chemical library from 309 compounds to 1858 compounds. Conclusions: Results from this analysis suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated from the peer-reviewed literature. Certainly, more research is required to put these screening level analyses into context, but our hope is that the information presented in this review facilitates development of new hypotheses by the research community.
