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UTILITY OF A NEUROBEHAVIORAL SCREENING BATTERY FOR DIFFERENTIATING THE EFFECTS OF TWO PYRETHROIDS PERMETHRIN AND CYPERMETHRIN
Citation:
McDaniel, K. AND V. Moser. UTILITY OF A NEUROBEHAVIORAL SCREENING BATTERY FOR DIFFERENTIATING THE EFFECTS OF TWO PYRETHROIDS PERMETHRIN AND CYPERMETHRIN. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-93/341.
Description:
The ability of a neurobehavioral screening battery to differentiate the effects of two pyrethroids, permethrin and cypermethrin, was assessed in this experiment. he tests pyrethroids, permethrin and cypermethrin, included a functional observational battery (FOB) and an automated measure of motor activity. uantitative, rank-order, and descriptive measures were combined to establish dose-response and time-course characteristics of these chemicals. lthough establish dose cc-cyano group, the behavioral the structures of these pesticides differ only in the te different. s syndromes associated with the Type I and II pyrethroids are qui previously reported for type I pyrethroids, permethrin produced a syndrome consisting of aggressive sparring behavior, fine to whole-body tremor, hyperthermia, and decreased motor activity. n addition decreased grip strengths, increased resistance to capture, increased reactivity to the click stimulus, shaking of the head and forelimbs, and withdrawal reactions were observed. n contrast, the type ii pyrethroid cypermethrin produced pawing and burrowing, salivation, whole body tremor to choreoathetosis, marked neuromuscular weakness and equilibrium changes, retropulsion, lateral head movements, alterations in the responses to various stimuli, hypothermia, increased urination, and lowered motor activity. arked neuromuscular alterations produced by cypermethrin included decreased grip strengths, altered gait and righting ability, and increased landing foot splay. espite some similarity in the effects of these pyrethroids on some behavioral measures, the-overall profiles using this battery of tests served to discriminate between the effects of these two compounds.