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INTERSPECIES SENSITIVITY TO CHEMICAL CARCINOGENS: RELATIONSHIPS BETWEEN MOUSE SKIN TUMORS AND HUMAN LUNG CANCER
Citation:
Nesnow, S. AND J. Lewtas. INTERSPECIES SENSITIVITY TO CHEMICAL CARCINOGENS: RELATIONSHIPS BETWEEN MOUSE SKIN TUMORS AND HUMAN LUNG CANCER. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/111 (NTIS PB92158674).
Description:
This review focuses on the relationships between mouse skin tumors and human lung cancer and discusses these relationships from several perspectives. hese perspectives include: mouse skin as an experimental test system; metabolic comparisons of the response of mouse skin and human lung; comparison of DNA binding in mouse skin and human lung tissues; patterns of oncogene mutations in mouse skin and human lung cancers; quantitative comparison of the tumorigenic effects of complex mixtures; use of similarity to apply the comparative potency approach to new mixtures. n general, in terms of tumorigenic response, both mouse skin and human lung respond to a number of the same chemicals. etabolically, it seems that both tissues are capable of metabolizing some of the major classes of chemicals carcinogens PAH's, nitrosamines to products that can bind to DNA. NA adducts from exposures to complex mixtures are detected in both mouse skin and human lung tissues. ariety of mutations are found in the Ha-ras/oncogene from the DNA from mouse skin tumors induced by chemical carcinogens and human lung tumor DNA seems to have similar mutations in the family of ras genes. uantitatively, in terms of tumor formation, the close agreement between the two, rankings: mouse skin tumors and human lung cancers for the four respiratory complex mixtures, serves to strengthen the argument for the use of the comparative potency method in risk assessment.