Notice:

EPA hosted an IRIS public science meeting on February 25-26, 2015, to provide an opportunity for the public to give input and participate in an open discussion regarding preliminary materials that were prepared for the IRIS chemicals, butyl benzyl phthalate (BBP), diisobutyl phthalate (DIBP), and dibutyl phthalate (DBP), prior to the development of the draft assessments.

Citation:

U.S. EPA. IRIS Toxicological Review of Diisobutyl Phthalate (Dibp) (Preliminary Assessment Materials). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/333, 2014.

Impact/Purpose:

The purpose of this document is to distribute preliminary materials for diisobutyl phthalate (DIBP). This information is distributed solely for the purpose of pre-dissemination review under applicable information quality guidelines. These preliminary materials include a planning and scoping summary, information on the approaches used to identify pertinent literature, results of the literature search, approaches for selection of studies for hazard identification, presentation of critical studies in evidence tables and exposure-response arrays, and mechanistic information for DIBP. These preliminary materials are being circulated for review of its technical accuracy and science policy implications. These materials will be posted on the EPA website to make them available to the public.

Description:

In September 2014, EPA released the draft literature searches and associated search strategies, evidence tables, and exposure response arrays for DIBP to obtain input from stakeholders and the public prior to developing the draft IRIS assessment. Specifically, EPA was interested in comments on the following:

• Draft literature search strategies
• The approach for identifying studies
• The screening process for selecting pertinent studies
• The resulting list of pertinent studies
• Preliminary evidence tables
  • The process for selecting studies to include in evidence tables
  • The quality of the studies in the evidence tables

The literature search strategy, which describes the processes for identifying scientific literature, contains the studies that EPA considered and selected to include in the evidence tables. The preliminary evidence tables and exposure-response arrays present the key study data in a standardized format. The evidence tables summarize the available critical scientific literature. The exposure-response figures provide a graphical representation of the responses at different levels of exposure for each study in the evidence table.

URLs/Downloads:

Scoping Information, Preliminary Literature Search, Associated Strategy and Evidence Tables for DIBP  (PDF, 152 pp,  1940  KB,  about PDF)

DIBP Errata Sheet  (PDF, 1 pp,  375  KB,  about PDF)

Primary literature search references sorted by author (DIBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

Literature selection process for the DIBP primary literature (dynamic literature link - generated by HERO, leaving the IRIS website)

Mechanistic table (DIBP) (dynamic literature link - generated by HERO, leaving the IRIS website)

Targeted literature search for epidemiological references sorted by author (phthalate) (dynamic literature link - generated by HERO, leaving the IRIS website)

Literature selection process for the DIBP targeted epidemiological literature (dynamic literature link - generated by HERO, leaving the IRIS website)

IRIS February 2015 Public Science Meeting & Presentations

Record Details:

Record Type:DOCUMENT( IRIS ASSESSMENT)

Product Published Date:12/15/2014

Record Last Revised:12/06/2016

OMB Category:Other

Record ID: 298811

Show Additional Record Data

Acronyms:

Title :IRIS Toxicological Review of Diisobutyl Phthalate (Dibp) (Preliminary Assessment Materials)

Version :1.0

Acronym :DIBP

Acronym Meaning :Diisobutyl Phthalate

Document IDs:

EPA Number :EPA/635/R-14/333