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CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN INCREASES WITH AGE IN THE MOUSE AND RAT BRAIN
Citation:
O'Callaghan, J. AND D. Miller. CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN INCREASES WITH AGE IN THE MOUSE AND RAT BRAIN. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/250 (NTIS PB92110535).
Description:
The role of aging in the expression of the astrocyte protein, glial fibrillary acidic protein (GFAP), was examined. n both mice and rats the concentration of GFAP increased throughout the brain as a function of aging. he largest increase (2-fold) was observed in striatum for both species. he neuron-specific proteins, synapsin I and neurofilament-200 were not altered by aging in any region of the fuse or rat brain. he data suggest that strocytic hypertrophy observed with aging involves an accumulation of glial filaments.
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CONCENTRATION OF GLIAL FIBRILLARY ACIDIC PROTEIN INCREASES WITH AGE IN THE MOUSE AND RAT BRAINRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
29843