Citation:

Gilbert, M., S. Acheson, C. Mack, AND K. Crofton. EXAMINATION OF THE PROCONVULSANT ACTION OF PYRETHROID INSECTICIDES USING PENTYLENETETRAZOL AND AMYGDALA KINDLING SEIZURE MODELS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/136 (NTIS PB91109744).

Description:

The seizure-inducing properties of two pyrethroids were assessed by pentylenetetrazol (PTZ) seizure models (repeated ip, suprathreshold ip, and iv), and electrical kindling of the amygdala. he efficacy of po versus ip routes of deltamethrin administration was compared using iv-PTZ administration and tests of locomotor activity in a figure-eight maze. he Type I pyrethroid, cismethrin (8 or 15 mg/kg), and the Type II pyrethroid, deltamethrin (6 or 10 mg/kg), were administered daily, 2 hours prior to electrical kindling stimulation. oth pyrethroids facilitated amygdala kindling to a minimal but equivalent degree, but only at dosages that also evoked strong behavioral signs of toxicity. ismethrin (15 mg/kg, po) produced a 17% reduction in the threshold dosage of ip-PTZ required to induce a seizure, while delaying the onset of generalized seizure activity. eltamethrin (10 mg/kg, po) failed to alter threshold or latency to seizure onset, but did increase seizure duration. o differences were revealed between po (0,10,15 mg/kg) or ip (0,1,10 mg/kg) administered deltamethrin on thresholds, seizure durations, latencies to myoclonic jerks, or generalized seizure activity following iv-PTZ. eizure severity, however, was enhanced by pyrethroids administered in the suprathreshold-ip and iv-PTZ tests. oth po and ip deltamethrin produced comparable decreases in motor activity. It was concluded that pyrethroids may possess some proconvulsant properties, but these are mild and occur at only high dosages. indling and suprarthreshold ip-PTZ appeared to be the most sensitive tests in the detection of convulsive potential.

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