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REGIONAL RESPIRATORY TRACT ABSORPTION OF INHALED REACTIVE GASES
Citation:
Miller, F., J. Overton, J. Kimbell, AND M. Russell. REGIONAL RESPIRATORY TRACT ABSORPTION OF INHALED REACTIVE GASES. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-92/179 (NTIS PB92217140).
Description:
Highly reactive gases present unique problems due to the number of actors which must be taken into account to determine regional respiratory tract uptake. We reviewed some of the physical, chemical, and biological factors that affect dose and that must be understood to interpret toxicological data, to evaluate experimental dosimetry studies, and to develop dosimetry models. elected dosimetry experiments involving laboratory animals and humans were discussed, showing the variability and uptake according to animal species and respiratory tract region for various reactive gases. ew experimental dosimetry approaches, such as those involving isotope ratio mass spectroscopy and cyclotron generation reactive gases, were discussed that offer great promise for improving our ability to study regional respiratory tract absorption of reactive gases. arious dosimetry modeling applications were discussed which demonstrate; the importance of airflow patterns for site-specific dosimetry in the upper respiratory tract, the influence of the anatomical model used to make inter- and intraspecies dosimetric comparisons, the influence of tracheobronchial path length on predicted dose curves, and the implications of ventilatory unit structure and volume on dosimetry and response. ollectively, these examples illustrate important aspects. of regional respiratory tract absorption of inhaled reactive gases. iven the complex nature of extent and pattern of injury in the respiratory tract from exposure to reactive gases, understanding interspecies differences in the absorption of reactive gases will continue to be an important area for study.
