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AOP description: Acetylcholinesterase inhibition
Citation:
Russom, C. AOP description: Acetylcholinesterase inhibition. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-14/035, 2014.
Impact/Purpose:
This adverse outcome pathway (AOP) leverages existing knowledge in the open literature to describe the linkage between inhibition of acetylcholinesterase (AChE) and the subsequent mortality resulting from impacts at cholinergic receptors. The AOP takes a chemical category approach, with supporting evidence provided for carbamate and organophosphate (OP) insecticides known to trigger the AChE inhibition AOP. Since AChE is found in vertebrate and invertebrate species, the pathway description will encompass these taxonomic groups.
Description:
This adverse outcome pathway (AOP) leverages existing knowledge in the open literature to describe the linkage between inhibition of acetylcholinesterase (AChE) and the subsequent mortality resulting from impacts at cholinergic receptors. The AOP takes a chemical category approach, with supporting evidence provided for carbamate and organophosphate (OP) insecticides known to trigger the AChE inhibition AOP. Since AChE is found in vertebrate and invertebrate species, the pathway description will encompass these taxonomic groups.
