EPA Science Inventory

The Risk Assessment in the 21st Century (RISK21): Roadmap and Matrix

Citation:

Embry, M., A. Bachman, D. Bell, A. Boobis, S. Cohen, M. Dellarco, I. Dewhurst, N. Doerrer, R. Hines, A. Moretto, T. Pastoor, R. Phillips, J. Rowlands, J. Tanir, D. Wolf, AND J. Doe. The Risk Assessment in the 21st Century (RISK21): Roadmap and Matrix. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 44:6-16, (2014).

Description:

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix. This paper describes in detail the process for using the roadmap and matrix. The purpose of this methodology is to optimize the use of prior information and testing resources (animals, time, facilities, and personnel) to efficiently and transparently reach a risk and/or safety determination. Based on the particular problem, exposure and toxicity data should have sufficient precision to make such a decision. Estimates of exposure and toxicity, bounded by variability and/or uncertainty, are plotted on the X- and Y-axes of the RISK21 matrix, respectively. The resulting intersection is a highly visual representation of estimated risk. Decisions can then be made to increase precision in the exposure or toxicity estimates or declare that the available information is sufficient. RISK21 represents a step forward in the goal to introduce new methodologies into 21st century risk assessment. Indeed, because of its transparent and visual process, RISK21 has the potential to widen the scope of risk communication beyond those with technical expertise.

Purpose/Objective:

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix. The purpose of this manuscript is to describe in detail the process for using the roadmap and matrix to optimize the use of prior information and testing resources (animals, time, facilities, and personnel) to efficiently and transparently reach a risk and/or safety determination.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Completion Date: 07/29/2014
Record Last Revised: 07/29/2014
Record Created: 07/29/2014
Record Released: 07/29/2014
OMB Category: Other
Record ID: 282375

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ASSOCIATE DIRECTOR FOR HEALTH