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Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised Aug 2014 External Review Draft)
EPA's Science Advisory Board (SAB) Staff Office has announced two meetings for the SAB Chemical Assessment Advisory Committee (CAAC), augmented for the review of the draft IRIS assessment of ethylene oxide (CAAC-Ethylene oxide panel). The first meeting is a public teleconference scheduled for September 30, 2014. The second is a face-to face panel meeting scheduled for November 18-20, 2014 in Arlington, VA. Additional information about participation in the external peer review meetings, including how to provide comments to the SAB, is available on the SAB website and via the Federal Register.
U.S. EPA. Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (Revised Aug 2014 External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-14/194A, 2014.
EPA is seeking peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene oxide (cancer) that will appear in the Integrated Risk Information System (IRIS) database.
EPA seeks external peer review on how the Agency responded to the SAB panel recommendations, the exposure-response modeling of epidemiologic data, including new analyses since the 2007 external peer review, and on the adequacy, transparency, and clarity of the revised draft. The peer review will include an opportunity for the public to address the peer reviewers.
URLs/Downloads:Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide (August 2014) (EPA/635/R-14/194a) (PDF,188 pp, 1488 KB, about PDF)
Note to Reviewers (August 2014) (PDF,3 pp, 42 KB, about PDF)
AGENCY RESPONSE (PDF,2 pp, 96 KB, about PDF)
SCIENCE ADVISORY BOARD REVIEW OF THE EPA’S EVALUATION OF THE INHALATION CARCINOGENICITY OF ETHYLENE OXIDE (REVISED EXTERNAL REVIEW DRAFT - AUGUST 2014) (PDF,52 pp, 376 KB, about PDF)
Peer Review Plan (PDF,NA pp, 33 KB, about PDF)
Formation of the Chemical Assessment Advisory Committee (CAAC) Augmented for the Ethylene Oxide Review (Memo, Jul 11, 2014) (PDF,6 pp, 53 KB, about PDF)
SAB FR Notice: Aug 11, 2014 Exit
SAB Project Page: IRIS Assessment for Ethylene Oxide (2014) - Evaluation of Inhalation Carcinogenicity
NCEA Draft Charge to the Reviewers (August 2014) (PDF,5 pp, 147 KB, about PDF)
Evaluation of the Inhalation Carcinogenicity of Ethylene Oxide - Appendices (August 2014) (EPA/635/R-14/194a) (PDF,284 pp, 2207 KB, about PDF)
Record Details:Record Type: DOCUMENT (IRIS ASSESSMENT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT
QUANTITATIVE AND RISK METHODS GROUP