EPA Science Inventory

High Throughput Exposure Prioritization of Chemicals Using a Screening-Level Probabilistic SHEDS-Lite Exposure Model

Citation:

Ozkaynak, H., K. Isaacs, J. Xue, Rocky Goldsmith, P. Egeghy, D. Vallero, AND J. Wambaugh. High Throughput Exposure Prioritization of Chemicals Using a Screening-Level Probabilistic SHEDS-Lite Exposure Model. Presented at Annual Joint Conference ISEE/ISES/ISIAQ, basel, SWITZERLAND, August 19 - 23, 2013.

Description:

These novel modeling approaches for screening, evaluating and classifying chemicals based on the potential for biologically-relevant human exposures will inform toxicity testing and prioritization for chemical risk assessment. The new modeling approach is derived from the Stochastic Human Exposure and Dose-Simulation Model (SHEDS) for multimedia pollutants.

Purpose/Objective:

The National Exposure Research Laboratory (NERL) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA mission to protect human health and the environment. HEASD research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.

URLs/Downloads:

ISEE 2013_CSS SHEDS-LITE POSTER_8-14-13.PPT

Record Details:

Record Type: DOCUMENT (PRESENTATION/POSTER)
Completion Date: 06/11/2014
Record Last Revised: 06/11/2014
Record Created: 06/11/2014
Record Released: 06/11/2014
OMB Category: Other
Record ID: 278257

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB