EPA Science Inventory

Adverse outcome pathways linked to population models as a methodology for investigating effects of chemical stressors

Citation:

Miller, D. AND G. Ankley. Adverse outcome pathways linked to population models as a methodology for investigating effects of chemical stressors. Presented at IAGLR Conference, Hamilton, ON, CANADA, May 26 - 30, 2014.

Description:

In addressing the complexity and toxicity of chemical contaminants in Great Lakes ecosystems, we describe an approach to link chemically induced alterations in molecular and biochemical endpoints to adverse outcomes in whole organisms and populations. Analysis of population impacts of chemical stressors through the use of modeling provides a linkage between endpoints observed in the individual (i.e. through effects based monitoring) and ecological risk to the population as a whole. Our approach employs a simple density dependent logistic matrix model linked to adverse outcome pathways (AOPs) for reproductive effects in fish of contaminants that impact different points within the hypothalamic-pituitarygonadal axis. As an example, quantitative relationships between estradiol, testosterone, and vitellogenin concentrations and fecundity established in fathead minnow (Pimephales promelas) 21-d reproduction studies with different HPG-active chemicals are used to forecast the effects on populations exposed to stressors that reduce vitellogenesis. A second example utilizes linked AOP and population models parameterized with long-term monitoring data for white sucker (Catostomus commersonii) collected from a study site at Jackfish Bay, Lake Superior to predict population trends over time, including after mitigation.

Purpose/Objective:

not applicable

URLs/Downloads:

MILLER ABSTRACT IAGLR.PDF   (PDF,NA pp, 81.416 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Completion Date: 06/10/2014
Record Last Revised: 06/10/2014
Record Created: 06/10/2014
Record Released: 06/10/2014
OMB Category: Other
Record ID: 278118

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION