EPA Science Inventory

Strategic approaches to adverse outcome pathway development

Citation:

Lettieri, T. AND D. Villeneuve. Strategic approaches to adverse outcome pathway development. Presented at SETAC Europe, Basel, SWITZERLAND, May 11 - 15, 2014.

Description:

Adverse outcome pathways (AOPs) are conceptual frameworks for organizing biological and toxicological knowledge in a manner that supports extrapolation of data pertaining to the initiation or early progression of toxicity to an apical adverse outcome that occurs at a level of organization relevant to risk assessment and/or regulatory decision-making. In order to support a more predictive paradigm in regulatory toxicology, organizations like the Organization for Economic Cooperation and Development (OECD), have initiated efforts to develop and disseminate AOP knowledge within the scientific community. While guidance on describing and evaluating AOPs has been provided, to date, generalized strategies for rapidly and systematically synthesizing available scientific evidence and knowledge into relevant AOPs are lacking. This presentation will report on results from an expert working group convened as part of an International Workshop on Advancing AOPs for Integrated Toxicology and Regulatory Applications to be held March 2-7, 2014. The workgroup will take the example of AOP development related to adverse impacts on avian reproduction as a case study to explore different strategies for AOP development. In particular, the group aims to examine (1) the use of molecular screening data to identify relevant molecular targets/potential initiating events; (2) the relative utility of biological systems knowledge versus literature and data-mining approaches to key event identification; (3) particular challenges related to development of AOPs for less studied organism classes (e.g. birds, aquatic organisms). An overview of approaches that did and did not work and a set of general recommendations for other AOP developers will be provided.

Purpose/Objective:

not applicable

URLs/Downloads:

ABSTRACT LETTIERI SETAC EUROPE 2014.PDF   (PDF,NA pp, 313.543 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/SLIDE)
Completion Date: 05/21/2014
Record Last Revised: 05/21/2014
Record Created: 05/21/2014
Record Released: 05/21/2014
OMB Category: Other
Record ID: 276369

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION