EPA Science Inventory

Pseudomonas aeruginosa Dose-Response and Bathing Water Infection

Citation:

Roser, D., B. van den Akker, S. Boase, C. Haas, N. Ashbolt, AND S. Rice. Pseudomonas aeruginosa Dose-Response and Bathing Water Infection. EPIDEMIOLOGY AND INFECTION. Cambridge University Press, New York, NY, 142(3):449-462, (2014).

Description:

Pseudomonas aeruginosa is the most commonly identified opportunistic pathogen associated with pool acquired bather disease. To better understand why this microorganism poses this protracted problem we recently appraised P. aeruginosa pool risk management. Much is known about the wider ecology of P. aeruginosa. However, in contrast to ingested and inhaled pathogens, neither the preceding exposure conditions, the dermal route of infection, nor infectious doses, appeared well-defined. The goal of this follow-up review is to explore these knowledge gaps through a survey of data and theory on: i) dose-response, i.e. bodily responses arising from different microbial doses [4] ; ii) Folliculitis and Acute Otitis Externa (AOE) aetiology; and iii) ecological processes preceding infection. The review commences with an introduction to P. aeruginosa pool disease attributes, research drivers and knowledge gaps, and microbial dose-response theory. Next Folliculitis and AOE aetiology relating to pools and experimental disease induction are reviewed, including uncertainties, notably whether P. aeruginosa might be autochthonous and whether Folliculitis should be viewed as multiple localised infections rather than a systemic infection. Biophysical steps whereby P. aeruginosa migrates from the pool void to the epidermis are reviewed in the third section. How to progress dose-response theory bearing in mind aetiology and ecology is then analysed. Finally, using all information we discuss management implications, propose a conceptual framework and identify priority research.

Purpose/Objective:

To review the literature so as to develop approaches to undertake dose-response modelling of the water-based pathogen Pseudomonas aeruginosa

URLs/Downloads:

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Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 05/08/2014
Completion Date: 05/08/2014
Record Last Revised: 06/03/2014
Record Created: 05/08/2014
Record Released: 05/08/2014
OMB Category: Other
Record ID: 275276

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB

MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT DIVISION

IMMEDIATE OFFICE