EPA Science Inventory

Dietary predictors of young children’s exposures to chlorpyrifos, permethrin, and 2,4-D using urinary biomonitoring

Citation:

Morgan, M. AND Paul-A Jones. Dietary predictors of young children’s exposures to chlorpyrifos, permethrin, and 2,4-D using urinary biomonitoring. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 62(2013):131-141, (2013).

Description:

Few data exist on the association between dietary habits and urinary biomarker concentrations of pesticides in children. The objective was to examined the association between the weekly intake frequency of 65 food items and urinary biomarkers of exposure to chlorpyrifos (3,5,6-trichloro-2-pyridinol [TCP]), permethrin (3-phenoxybenzoic acid [3-PBA]), and 2,4-dichlorophenoxyacetic acid [2,4-D] in 135 preschoolaged children. TCP and 3-PBA are nonspecific biomarkers as they are also urinary metabolites of other pesticides. TCP, 3-PBA, and 2,4-D were detected in 99%, 64%, and 92% of the urine samples, respectively. Mean urinary TCP concentrations were statistically significantly higher in children consuming fresh apples (9.40 ± 15.5 ng/mL versus 5.76 ± 3.57 ng/mL, p = 0.040) and fruit juices (8.41 ± 11.5 ng/mL versus 4.11 ± 2.77 ng/mL, p = 0.020) P3 times a week compared to <3 times a week. For 3-PBA, mean urinary metabolite concentrations were statistically significantly greater in children consuming chicken/turkey meats (0.79 ± 0.81 versus 0.41 ± 0.39, p = 0.013) P3 times a week compared to <3 times a week. No association occurred between the consumption of any food item and children’s mean urinary 2,4-D concentrations by intake group. In conclusion, frequent consumption of fresh apples and fruit juices or chicken/turkey meats were significant dietary predictors of urinary levels of TCP or 3-PBA, respectively. p = 0.040 is p p = 0.020 is p P3 = ≥ 3

Purpose/Objective:

The National Exposure Research Laboratory′s (NERL′s) Human Exposure and Atmospheric Sciences Division (HEASD) conducts research in support of EPA′s mission to protect human health and the environment. HEASD′s research program supports Goal 1 (Clean Air) and Goal 4 (Healthy People) of EPA′s strategic plan. More specifically, our division conducts research to characterize the movement of pollutants from the source to contact with humans. Our multidisciplinary research program produces Methods, Measurements, and Models to identify relationships between and characterize processes that link source emissions, environmental concentrations, human exposures, and target-tissue dose. The impact of these tools is improved regulatory programs and policies for EPA.

URLs/Downloads:

Food and Chemical Toxicology   Exit

MORGAN FINAL FINAL MANUSCRIPT7-22-13(CLEAN)REV.PDF   (PDF,NA pp, 220.727 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 05/08/2014
Completion Date: 05/08/2014
Record Last Revised: 05/08/2014
Record Created: 05/08/2014
Record Released: 05/08/2014
OMB Category: Other
Record ID: 275275

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL EXPOSURE RESEARCH LAB

HUMAN EXPOSURE AND ATMOSPHERIC SCIENCES DIVISION

EXPOSURE MEASUREMENTS & ANALYSIS BRANCH