EPA Science Inventory

CROSS-SPECIES EVALUATION OF ENDOCRINE DISRUPTING EFFECTS OF LEAD (Pb) on MATURATION AND DEVELOPMENT

Citation:

Hines, E., L. Vinikoor-Imler, AND Meredith Lassiter. CROSS-SPECIES EVALUATION OF ENDOCRINE DISRUPTING EFFECTS OF LEAD (Pb) on MATURATION AND DEVELOPMENT. Presented at Society of Toxicology, phoenix, Az, March 22 - 27, 2014.

Description:

In a cross-species evaluation conducted in support of the review of the US EPA National Ambient Air Quality Standards (NAAQS) for Lead (Pb), findings from epidemiologic, toxicological and ecological disciplines were used in a weight of evidence approach to evaluate reproductive and developmental effects of this metal, including endpoints associated with endocrine disruption. In the process of synthesizing information on reproductive effects of Pb for the 2013 Integrated Science Assessment for Lead (ISA), we noted that Pb is associated with maturational delays (e.g. puberty onset, developmental duration, life cycle length, metamorphosis) across a wide variety of organisms. A causal association between Pb exposure and developmental and reproductive endpoints for both human health and ecological receptors was reported. Moving beyond the synthesis conducted for the Pb ISA, we have reviewed the literature on changes in timing of developmental milestones associated with exposure to Pb. Evidence from multiple species points to an underlying common mode of action of Pb on the insulin-like growth factor signaling pathway; inhibin B was also affected in vertebrate models of Pb exposure. An interdisciplinary cross-species approach provided insights into endocrine disruption by Pb and a possible mode of action of this metal. Increased time to sexual maturation or delayed development may have consequences for reproduction and development across a broad range of species.

Purpose/Objective:

This poster for the SOT annual meeting speaks to the cross-species evaluation of endocrine disrupting effects of the metal lead (Pb) on organismal maturation and development.

URLs/Downloads:

SOT PBPOSTER 2014 HINES PRINT.PPTX

HINES SOT 2014 POSTER KIRRANE TMRF_363V2.PDF   (PDF,NA pp, 21.227 KB,  about PDF)

Record Details:

Record Type: DOCUMENT (PRESENTATION/POSTER)
Completion Date: 04/11/2014
Record Last Revised: 04/11/2014
Record Created: 04/11/2014
Record Released: 04/11/2014
OMB Category: Other
Record ID: 273139

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT